Contribution of dfrA and inhA Mutations to the Detection of Isoniazid-Resistant Mycobacterium tuberculosis. - Related Articles
Contribution of dfrA and inhA Mutations to the Detection of Isoniazid-Resistant Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 2009 Jul 6;
Authors: Ho YM, Sun YJ, Wong SY, Lee AS
Screening of 127 isoniazid (INH)-resistant Mycobacterium tuberculosis (MTB) isolates from Singapore for mutations within the dfrA and inhA genes revealed mutations in none and 5 (3.9%) isolates respectively, implying that mutations in dfrA do not contribute to the detection of INH-resistant MTB, and that mutations within inhA are rare. Thirty-seven (29%) of 127 isolates had no mutations in any of the genes implicated in INH-resistance (katG, kasA, ndh; inhA and ahpC promoters), suggesting that there are new INH targets yet to be discovered.
PMID: 19581462 [PubMed - as supplied by publisher] [Tuberculosis Pulmonary]