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Antimycobacterial Activity of Exocarpos latifolius is due to Exocarpic Acid.

Submitted by Editor on Mon, 05/18/2009 - 16:02

Antimycobacterial Activity of Exocarpos latifolius is due to Exocarpic Acid. - Related Articles
Antimycobacterial Activity of Exocarpos latifolius is due to Exocarpic Acid.
Planta Med. 2009 May 14;
Authors: Koch M, Bugni TS, Pond CD, Sondossi M, Dindi M, Piskaut P, Ireland CM, Barrows LR
Lipophilic fractions of stem extracts from EXOCARPOS LATIFOLIUS, native to Papua New Guinea, showed significant activity against MYCOBACTERIUM TUBERCULOSIS H37Ra. Bioactivity-guided fractionation yielded exocarpic acid ( E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against MYCOBACTERIUM TUBERCULOSIS H37Ra.
PMID: 19444772 [PubMed - as supplied by publisher] [Tuberculosis Pulmonary]