CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts - a bioinformatical analysis. - Related Articles
CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts - a bioinformatical analysis.
Biol Chem. 2009 Aug 10;
Authors: Xiao K, Jehle F, Peters C, Reinheckel T, Schirmer RH, Dandekar T
Abstract In genome-wide screens, we studied CA/C1 peptidases of malaria-causing plasmodia and their hosts (man and mouse). For Plasmodium falciparum and P. berghei, several new CA/C1 peptidase genes encoding proteases of the L- and B-family with specific promoter modules were identified. In addition, two new human CA/C1 peptidase loci and one new mouse gene locus were found; otherwise the sets of CA/C1 peptidase genes in man and mouse appear to be complete now. In each studied species there is a multitude of CA/C1 peptidases with lysosomal localization signals and partial functional overlap according to similar but subfamily-specific structures. Individual target structures in plasmodia include residues specifically different in CA/C1 peptidase subsite 2. This is of medical interest when considering CA/C1 peptidase inhibition for chemotherapy in malaria, malignancies and other diseases. Promoter structure and mRNA regulation differ widely among CA/C1 peptidase subfamilies and between mammals and plasmodia. We characterized promoter modules conserved in mouse and man for the CA/C1 peptidase families B and L (with L-like subfamily, F-like subfamily and mouse specific J-like subfamily). RNA motif searches revealed conserved regulatory elements such as GAIT elements, plasmodial CA/C1 peptidase mRNA elements include ARE elements and mammalian mRNAs used 15-lox DICE elements.
PMID: 19663681 [PubMed - as supplied by publisher] [PubMed-Malaria]